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Index » Radio Paradise/General » General Discussion » COVID-19 Page: Previous  1, 2, 3 ... 47, 48, 49 ... 395, 396, 397  Next
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R_P

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Gender: Male


Posted: Mar 22, 2022 - 8:24pm

 Animal-Farm wrote:
You do understand that Omnicron is less mild than the flu.

Many articles recently printed.

Are you sure?

Animal-Farm

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Posted: Mar 22, 2022 - 8:23pm

 R_P wrote:

Flu BS. Rinse. Repeat.

Oh, are they? I thought it was the experimental gene therapy.

PS.: Like you trust medicine and pharma. Huge concern troll there.


You do understand that Omnicron is less mild than the flu.

Many articles recently printed.
R_P

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Gender: Male


Posted: Mar 22, 2022 - 8:20pm

 Animal-Farm wrote:
something less mild than the flu. It is over-reach and will destroy trust in medicine and pharma. The mandates are the problem.

Flu BS. Rinse. Repeat.

Oh, are they? I thought it was the experimental gene therapy.

PS.: Like you trust medicine and pharma. Huge concern troll there.
Animal-Farm

Animal-Farm Avatar



Posted: Mar 22, 2022 - 8:15pm

 R_P wrote:

None were mandatory. I have had many vaccines incl. for weird tropical diseases (mandatory for going to some places). I'm still here, Neo.

You OTOH are a victim without a crime. Everyone's out to get you injected!!!1!11!!!



I think vaccines should be a choice. However, for tens of millions in the USA they are required.

So your cavalier attitude is fine for you, but put yourself in some other person's shoes, this pandemic is over, and yet they must be multiple-injected to keep thier crummy  job with a vaccine for a 2019 coronavirus for something less mild than the flu. It is over-reach and will destroy trust in medicine and pharma. The mandates are the problem. If you want to take it fine, but for the person emptying the trash cans to be mandated? Huge over-reach.
Animal-Farm

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Posted: Mar 22, 2022 - 8:12pm

Lavishly funded Moderna hits safety problems in bold bid to revolutionize medicine

STAT News

This is the stuff you are injecting again and again into yourself

    By Damian Garde Jan. 10, 2017

    It was to be the first therapy using audacious new technology that Bancel promised would yield dozens of drugs in the coming decade.

    But the Crigler-Najjar treatment has been indefinitely delayed, an Alexion spokeswoman told STAT. It never proved safe enough to test in humans, according to several former Moderna employees and collaborators who worked closely on the project. Unable to press forward with that technology, Moderna has had to focus instead on developing a handful of vaccines, turning to a less lucrative field that might not justify the company’s nearly $5 billion valuation.

    Bancel made no mention of the Crigler-Najjar drug when he spoke Monday before a similarly packed room at this year’s J.P. Morgan conference.

    His presentation instead focused on four vaccines that the company is moving through the first phase of clinical trials: two target strains of influenza, a third is for Zika virus, and the fourth remains a secret. Bancel clicked through graphs of data from animal studies before hurrying on to tout Moderna’s balance sheet and discuss the company’s cancer vaccines, slated for clinical testing later this year.

    When STAT asked Bancel after the presentation about Crigler-Najjar, he deferred to Alexion.

    In need of a Hail Mary

    Founded in 2012, Moderna reached unicorn status — a $1 billion valuation — in just two years, faster than Uber, Dropbox, and Lyft, according to CB Insights. The company’s premise: Using custom-built strands of messenger RNA, known as mRNA, it aims to turn the body’s cells into ad hoc drug factories, compelling them to produce the proteins needed to treat a wide variety of diseases.

    But mRNA is a tricky technology. Several major pharmaceutical companies have tried and abandoned the idea, struggling to get mRNA into cells without triggering nasty side effects.

    Bancel has repeatedly promised that Moderna’s new therapies will change the world, but the company has refused to publish any data on its mRNA vehicles, sparking skepticism from some scientists and a chiding from the editors of Nature.

    The indefinite delay on the Crigler-Najjar project signals persistent and troubling safety concerns for any mRNA treatment that needs to be delivered in multiple doses, covering almost everything that isn’t a vaccine, former employees and collaborators said.

    The company did disclose a new technology on Monday that it says will more safely deliver mRNA. It’s called V1GL. Last month, Bancel told Forbes about another new technology, N1GL.

    But in neither case has the company provided any details. And that lack of specificity has inevitably raised questions.

    Three former employees and collaborators close to the process said Moderna was always toiling away on new delivery technologies in hopes of hitting on something safer than what it had. (Even Bancel has acknowledged, in an interview with Forbes, that the delivery method used in Moderna’s first vaccines “was not very good.”)

    Are N1GL and V1GL better? The company has produced no data to answer that question. When STAT asked about new technologies, Bancel referred questions to the company’s patent filings.

    The three former employees and collaborators said they believe N1GL and V1GL are either very recent discoveries, just in the earliest stages of testing — or else new names slapped on technologies Moderna has owned for years.

    “ would have to be a miraculous, Hail Mary sort of save for them to get to where they need to be on their timelines,” one former employee said. “Either is extremely confident that it’s going to work, or he’s getting kind of jittery that with a lack of progress he needs to put something out there.”

    A bug in the software

    Bancel, a first-time biotech CEO, has dismissed questions about Moderna’s potential. He describes mRNA as a simple way to develop treatments for scores of ailments. As he told STAT over the summer, “mRNA is like software: You can just turn the crank and get a lot of products going into development.”

    It seems clear, however, that the software has run into bugs.

    Patients with Crigler-Najjar are missing a key liver enzyme needed to break down bilirubin, a yellowish substance that crops up in the body as old red blood cells break down. Without that enzyme, bilirubin proliferates in the blood, leading to jaundice, muscle degeneration, and even brain damage.

    In Moderna’s eyes, the one-in-million disease looked like an ideal candidate for mRNA therapy. The company crafted a string of mRNA that would encode for the missing enzyme, believing it had hit upon an excellent starting point to prove technology could be used to treat rare diseases.

    But things gradually came apart last year.

    Every drug has what’s called a therapeutic window, the scientific sweet spot where a treatment is powerful enough to have an effect on a disease but not so strong as to put patients at too much risk. For mRNA, that has proved elusive.

    In order to protect mRNA molecules from the body’s natural defenses, drug developers must wrap them in a protective casing. For Moderna, that meant putting its Crigler-Najjar therapy in nanoparticles made of lipids. And for its chemists, those nanoparticles created a daunting challenge: Dose too little, and you don’t get enough enzyme to affect the disease; dose too much, and the drug is too toxic for patients.

    From the start, Moderna’s scientists knew that using mRNA to spur protein production would be a tough task, so they scoured the medical literature for diseases that might be treated with just small amounts of additional protein.

    “And that list of diseases is very, very short,” said the former employee who described Bancel as needing a Hail Mary.

    Crigler-Najjar was the lowest-hanging fruit.

    Yet Moderna could not make its therapy work, former employees and collaborators said. The safe dose was too weak, and repeat injections of a dose strong enough to be effective had troubling effects on the liver in animal studies.

    The drug, ALXN1540, has since been delayed, as Moderna works on “new and better formulations” that might later reach human trials, Alexion said in an emailed statement.

    A huge valuation but a modest pipeline

    The failure in its first and most advanced therapy casts doubt on Moderna’s other goals for the rare disease space.

    It also calls into question Moderna’s valuation, pegged at $4.7 billion by Pitchbook. The company has raised nearly $2 billion in cash from investors and partners. But it has done so by promising a revolutionary technology safe enough to deliver repeated doses of mRNA.

    The drugs it is pushing along now, by contrast, are more modest, relying on single administrations of mRNA. Beyond the four vaccines, it has one early-stage clinical trial targeting cardiac disease, launched just last month by partner AstraZeneca. The treatment involves a one-time dose and doesn’t use the tricky nanoparticle casing.

    Until Moderna demonstrates that its technology can safely treat a disease, those questions will be tough to answer.

    “My friends ask if they are like Theranos, and I say no; I think it’s a real idea,” one former Moderna collaborator said. “The question is how well does it work.”

    Bancel isn’t providing the data that could answer that. But he projects unbounded confidence.

    “I’m sure that five years from now we’ll look at 2017 as the inflection point that Moderna went for a liftoff,” he said at Monday’s presentation. “We have a chance to transform medicine, and we won’t quit until we are done and we have impacted patients.”


    R_P

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    Gender: Male


    Posted: Mar 22, 2022 - 8:07pm

     Animal-Farm wrote:
    You have taken  a couple of injections.

    But when you are requested to take the next one, and the next one, and the next one

    Whenever your employer or municipality says so.

    People's bodies are not pin-cushions, they can't handle it.

    The founder of Moderna said so himself, that it mRNA was probably going to for simple uses, not repetitive injections. From 2016 interview.

    None were mandatory. I have had many vaccines incl. for weird tropical diseases (mandatory for going to some places). I'm still here, Neo.

    You OTOH are a victim without a crime. Everyone's out to get you injected!!!1!11!!!

    R_P

    R_P Avatar

    Gender: Male


    Posted: Mar 22, 2022 - 8:04pm

     MayBaby wrote:
    LOL see?

    Yeah, I saw. You use SHILL and TROLL. Very high-minded.

    MayBaby

    MayBaby Avatar

    Location: Savannah, Georgia
    Gender: Female


    Posted: Mar 22, 2022 - 7:58pm


    Animal-Farm

    Animal-Farm Avatar



    Posted: Mar 22, 2022 - 7:56pm

     R_P wrote:

    Ok, Neo.



    You have taken  a couple of injections.

    But when you are requested to take the next one, and the next one, and the next one

    Whenever your employer or municipality says so.

    People's bodies are not pin-cushions, they can't handle it.

    The founder of Moderna said so himself, that it mRNA was probably going to for simple uses, not repetitive injections. From 2016 interview.
    MayBaby

    MayBaby Avatar

    Location: Savannah, Georgia
    Gender: Female


    Posted: Mar 22, 2022 - 7:56pm

     R_P wrote:

    LOL. Back to the dwarf pony.



    LOL see?

    R_P

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    Gender: Male


    Posted: Mar 22, 2022 - 7:51pm

     MayBaby wrote:
    TROLL

    LOL. Back to the dwarf pony.

    R_P

    R_P Avatar

    Gender: Male


    Posted: Mar 22, 2022 - 7:50pm

     Animal-Farm wrote:
    Nope, you are listening to the paid media and paid politicians and paid doctors. 

    Your yoga studio does not pay into the system. It is run for the benefit of pharma.

    Ok, Neo.

    MayBaby

    MayBaby Avatar

    Location: Savannah, Georgia
    Gender: Female


    Posted: Mar 22, 2022 - 7:50pm

     R_P wrote:

    Even if true, so what? You've used them. Crying time?

    Here's another: ad populum.



    TROLL
    MayBaby

    MayBaby Avatar

    Location: Savannah, Georgia
    Gender: Female


    Posted: Mar 22, 2022 - 7:49pm

     I really do have to get some sleep. 
    You that are monetarily  independent, just go ahead. 
    G'night.
    R_P

    R_P Avatar

    Gender: Male


    Posted: Mar 22, 2022 - 7:49pm

     MayBaby wrote:
    You did. everyone who looks at this sees it.

    Even if true, so what? You've used them. Crying time?

    Here's another: ad populum.
    Animal-Farm

    Animal-Farm Avatar



    Posted: Mar 22, 2022 - 7:49pm

     R_P wrote:

    You've gone down the rabbit hole. You're lost.



    Nope, you are listening to the paid media and paid politicians and paid doctors. 

    Your yoga studio does not pay into the system. It is run for the benefit of pharma.
    R_P

    R_P Avatar

    Gender: Male


    Posted: Mar 22, 2022 - 7:47pm

     Animal-Farm wrote:

    Once you see it...


    You've gone down the rabbit hole. You're lost.

    MayBaby

    MayBaby Avatar

    Location: Savannah, Georgia
    Gender: Female


    Posted: Mar 22, 2022 - 7:47pm

     R_P wrote:

    None. Questions and things you've offered...



    You did. everyone who looks at this sees it.
    R_P

    R_P Avatar

    Gender: Male


    Posted: Mar 22, 2022 - 7:46pm

     MayBaby wrote:

     the tyranny that has  insidiously taken us over.


    Insert Twilight Zone music here...

    R_P

    R_P Avatar

    Gender: Male


    Posted: Mar 22, 2022 - 7:45pm

     MayBaby wrote:
    ad hominin much?

    None. Questions and things you've offered...

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